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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Ubiquitin-specific protease 22 is critical to in vivo angiogenesis, growth and metastasis of non-small cell lung cancer

Fig. 3

USP22 knockout suppresses angiogenesis and growth of A549 and H1299 cells. a. Colony formation assays, results show colonies formed within 3 weeks, compared to their parent cells, ** P < 0.01. b. The in vivo growth volumes of the USP22−/− and the parent A549 and H1299 cells (USP22−/− versus USP22+/+, ** P < 0.01). c. Represent images and average weights of xenografts (USP22−/− versus USP22+/+, ** P < 0.01). d. IHC stains for endothelial cell marker CD31, proliferation marker Ki67, and USP22 in xenografts generated by the USP22−/− and the parent USP22+/+ cancer cells (magnification, × 200)

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Cell Communication and Signaling

ISSN: 1478-811X