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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Targeting bone morphogenetic protein receptor 2 sensitizes lung cancer cells to TRAIL by increasing cytosolic Smac/DIABLO and the downregulation of X-linked inhibitor of apoptosis protein

Fig. 6

BMP inhibitors increase DNA double-stranded break (DSB) and the production of ROS. a H1299 cells treated with 2.5 μM JL5 demonstrate an increase percentage of dead cells over time. b-c The percentage of H1299 cells with DSB after treatment with JL5 and DMH2 was determined using the TUNEL Assay. JL5 and DMH2 both increased the percentage of cells with DSB over time. d After 24 h, TRAIL effects on DSB was not effected by the addition of JL5. e-g ROS production from H1299 cells treated with JL5 and TRAIL alone and in combination over time. JL5 but not TRAIL increased ROS production. JL5 did not enhance TRAIL induced ROS production. In each set of studies the data represents the mean of at least 4 independent experiments

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Cell Communication and Signaling

ISSN: 1478-811X