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Fig. 9 | Cell Communication and Signaling

Fig. 9

From: TPP-related mitochondrial targeting copper (II) complex induces p53-dependent apoptosis in hepatoma cells through ROS-mediated activation of Drp1

Fig. 9

Illustration of the mechanism of CTB-induced apoptosis in SMMC-7721 cells. CTB induces excessive ROS production, and is able to facilitate ROS-mediated Drp1 activation, mitochondrial p53 accumulation, collapses of MMP, opening of mMTP and subsequent hepatoma cells apoptosis. Mitochondrial p53 is crucial for CTB-mediated cell apoptosis, which is associated with Bax mitochondrial recruiting and mitochondrial Cyt C releasing

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Cell Communication and Signaling

ISSN: 1478-811X