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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: TPP-related mitochondrial targeting copper (II) complex induces p53-dependent apoptosis in hepatoma cells through ROS-mediated activation of Drp1

Fig. 1

CTB inhibits cell proliferation and induces cell cycle arrest in HCC. a Chemical structure and molecular formula of CTB. b HepG2, SMMC-7721, BEL-7402, Huh-7, Hep3B and LO2 cells were treated with CTB at different concentrations for 24 h, and the IC50 values were quantified using the MTT assay. c HepG2, SMMC-7721, BEL-7402 cells were treated with different CTB concentrations (0, 0.5, 1, 2, 4, 8, 16 or 20 μM) for 12, 24, 48 h, and cell viability was determined by the MTT assay. d Cell cycle analysis by flow cytometry. Percentages of cell cycle distributions were determined. Data are represented as the mean ± SD (n = 3). *P < 0.05, **P < 0.01 and ***P < 0.001 vs Control

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