Fig. 4
From: S100P is a molecular determinant of E-cadherin function in gastric cancer
The combination of S100P and E-cadherin molecular profiles defines subgroups with different clinical outcomes. a Representative images of S100P and E-cadherin protein expression detected by immunohistochemistry in a gastric carcinoma TMA. Manual annotation of each histological sample was performed by an experienced pathologist and cases were dichotomised using a simplified classification scheme considering retaining (graded as 3+) versus loss of marker from 0 to 2+. b Kaplan-Meier curves showing the probability of overall survival for patients with GC according to S100P expression. c Kaplan-Meier curves showing the probability of overall survival for patients with GC according to E-cadherin expression, indicating that loss of E-cadherin expression associates with a poorer overall survival. d Survival plot depicting the overall survival of patients according to four molecular phenotypes defined by the loss/retention of E-cad and S100P expression. Although not statistically significant, patients presenting the E-cadloss/S100Pret molecular phenotype follow a survival curve under that of all other patients