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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Platelets promote breast cancer cell MCF-7 metastasis by direct interaction: surface integrin α2β1-contacting-mediated activation of Wnt-β-catenin pathway

Fig. 3

The effect of Wnt-β-catenin signaling and integrin α2β1-mediated contacting on the invasion of MCF-7 cells. a The expression of β-catenin protein in the cytoplasm and nucleus of the MCF-7 after co-incubation with platelets, releasates, and pellets was detected by western blotting. b The effect of platelets, releasates, and pellets on the MCF-7 cell invasion with or without the treatment of XAV, an inhibitor for Wnt-β-catenin. MCF-7 cells were transfected with Sh-integrin α2β1. Then the percentage of α2β1-positive MCF-7 cells (c), the expression of integrin α2β1 in MCF-7 cells (d), the number of invasive MCF-7 cells (e), and the expression of β-catenin in MCF-7 cytoplasm and nucleus (f) were detected. Scale bar = 100 μm. *p < 0.05, **p < 0.01, ##p < 0.01

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Cell Communication and Signaling

ISSN: 1478-811X