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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: ΗΙF1α, EGR1 and SP1 co-regulate the erythropoietin receptor expression under hypoxia: an essential role in the growth of non-small cell lung cancer cells

Fig. 6

Expressions of phosphor-EPO-R (pEPO-R), HIF1α, SP1 and EGR1 in the NSCLC clinical specimens. a Immunohistochemical staining and scoring b of pEPO-R, HIF1α, SP1 and EGR1 in clinical NSCLC specimens or normal controls. Bars = 50 μM. c Correlation analysis of HIF1α, SP1 and EGR1 with pEPO-R expression in NSCLC. d RT-PCR analysis of HIF1α, HIF2α, SP1 and EGR1–4 mRNA expression in the NSCLC cell lines under normoxic condition. Mean ± SD; *, P < 0.05. e A diagram depicts how HIF1α, EGR1, and SP1 regulate EPO-R expression under normoxic condition in HBEC and NSCLC

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Cell Communication and Signaling

ISSN: 1478-811X