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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: SUMO3 modification by PIAS1 modulates androgen receptor cellular distribution and stability

Fig. 6

Inability of PIAS1(K117 L) to promote cytoplasmic translocation of AR from nucleus. (a) DU145 cells were transiently co-transfected with flag-AR, GFP-SUMO3 and myc-PIAS1 or myc-PIAS1 (K117 L) for 48 h or 72 h. Cells were fixed and stained with anti-flag mouse monoclonal antibody(red). Nuclei were visualized by DAPI staining. Representative images of transfected cells were shown. (b) DU145 cells were transiently co-transfected with flag-AR, GFP-SUMO3 and myc-PIAS1 or myc-PIAS1 (K117 L) for 48 h. Cells were fixed and stained with anti-myc mouse monoclonal antibody (red). Nuclei were visualized by DAPI staining. Representative images of transfected cells were shown

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