Skip to main content
Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer

Fig. 4

KPNA2 and stathmin/STMN1 expression are correlated in human HCC. a Representative micrographs show human HCC samples either H&E stained (upper row) or immunostained with KPNA2 (middle row) or stathmin (lower row). Scale bar: 100 μm. b Boxplots illustrate increasing immunohistochemical (IHC) scores of KPNA2 (upper panel) or stathmin (lower panel) with tumor dedifferentiation (G1 = well differentiated, G2 = moderately differentiated, G3–4 = poorly differentiated). c Spearman correlation between KPNA2 and STMN1 mRNA expression in a large HCC cohort (Roessler cohort). STMN1 is correlated to E2F1 and TFDP1 in human HCC. d, e Spearman correlation between STMN1 and E2F1 (d) or TFDP1 (e) expression in human HCC samples (Roessler cohort). High expression of KPNA2 and STMN1 correlates with poor prognosis in HCC patients. Overall survival of HCC patients showing low and high mRNA expression of KPNA2 (f) and STMN1 (g) or both (h) (cut-off: median, Roessler cohort)

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X