Fig. 2

KPNA2 depletion reduces the clonogenic capacity and cell migration of HCC cells being phenocopied by stathmin knockdown. a, b HLE cells were treated either with ctrl. or KPNA2 siRNAs and colony formation was analyzed 14 days after treatment by crystal violet staining (n = 4; p < 0.05 (*)). c, d HLE cells were treated either with ctrl. or stathmin siRNAs and colony formation assays were performed as described in (a) (n = 4; p < 0.05 (*)). e, f HLE cells were treated as described in (a) and two-dimensional scratch assays were started 48 h later. Gap closure was analyzed 18 h after scratching (n = 4; p < 0.05 (*)). g, h HLE cells were treated as described in (c) and scratch assays were performed as described in (e) (n = 4; p < 0.05 (*))