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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: Epithelial and interstitial Notch1 activity contributes to the myofibroblastic phenotype and fibrosis

Fig. 8

Injury-induced epithelial and interstitial Notch1 activity contributes to myofibroblastic phenotype and fibrosis. Injury stimulates the activation of the Notch1 signalling pathway in TECs and fibroblasts. Activated Notch1 signalling starts with a TGF-β1/Smad2/3 signalling cascade, which induces the EMT and FMD response, promotes myofibroblastic phenotype and ECM deposition, and results in interstitial fibrosis. Pharmacologic or genetic blockade of Notch1 signalling decreases TGF-β1 expression and abolishes injury-mediated EMT/FMD, myofibroblastic phenotype and fibrosis

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