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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Epithelial and interstitial Notch1 activity contributes to the myofibroblastic phenotype and fibrosis

Fig. 7

Notch1 activity mediates myofibroblastic phenotype dependent on TGF-β1 in vitro. a The mRNA expression levels of TGF-β1R, Col3α1 and α-SMA in NRK52E and NRK-49F cells treated with TGF-β1 with or without pcDNA3.1-NICD plasmid or NICD siRNA. b The protein expression levels of TGF-β1R, α-SMA and collagen III in NRK52E and NRK-49F cells treated with TGF-β1 with or without pcDNA3.1-NICD plasmid or NICD siRNA. c The mRNA expression levels of Smad2 and Smad3 in NRK52E and NRK-49F cells treated with TGF-β1 with or without pcDNA3.1-NICD plasmid or NICD siRNA. d The protein expression and phosphorylation levels of Smad2 and Smad3 in NRK52E and NRK-49F cells treated with TGF-β1 with or without pcDNA3.1-NICD plasmid or NICD siRNA. All data are presented as means ± SDs. TGF-β1, 5 ng/ml. *P < 0.05, versus the control; #P < 0.05 versus the TGF-β1-treated group; §P < 0.05 versus the pcDNA3.1-NICD plasmid-treated group

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