Skip to main content
Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Epithelial and interstitial Notch1 activity contributes to the myofibroblastic phenotype and fibrosis

Fig. 6

TGF-β1 induces Notch1 signalling activation during the EMT and FMD in vitro. a RTCA assay indicated the survival index of NRK-52E cells treated with TGF-β1 with or without DAPT. b RTCA assay indicated the survival index of NRK-49F cells treated with TGF-β1 with or without DAPT. c Increased mRNA expression levels of Notch1, Jagged1, Hey1, Col1α1, Col3α1, and α-SMA in TGF-β1-treated NRK-52E cells were inhibited by DAPT. d Increased mRNA expression levels of Notch1, Jagged1, Hey1, Col1α1, Col3α1, and α-SMA in TGF-β1-treated NRK-49F cells were inhibited by DAPT. e Elevated expression levels of NICD, Notch1 and Jagged1 in TGF-β1-treated NRK-52E cells were inhibited by DAPT. f Elevated expression levels of NICD, Notch1 and Jagged1 in TGF-β1-treated NRK-49F cells were inhibited by DAPT. All data are presented as means ± SDs. TGF-β1, 5 ng/ml. DAPT (HD), high-dose (10 μmol/L); DAPT (LD), low-dose (1 μmol/L). *P < 0.05, versus the control; #P < 0.05 versus the TGF-β1-treated group

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X