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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Epithelial and interstitial Notch1 activity contributes to the myofibroblastic phenotype and fibrosis

Fig. 4

Activated Notch1 signalling induces myofibroblastic phenotype in vitro. a Increased mRNA expression levels of Notch1 and Numb in Jag1-fc-treated NRK-52E and NRK-49F cells were strengthened by TGF-β1. b Upregulated NICD expression and nuclear localization in Jag1-fc-treated NRK-52E and NRK-49F cells were strengthened by TGF-β1. Bar = 20 μm. c Increased mRNA expression levels of Col3α1 and α-SMA in Jag1-fc-treated NRK-52E and NRK-49F cells were enhanced by TGF-β1. d Increased expression of α-SMA and vimentin in Jag1-fc-treated NRK-52E cells or NRK-49F cells were enhanced by TGF-β1. e Elevated expression of α-SMA and collagen III in Jag1-fc-treated NRK-52E and NRK-49F cells was strengthened by TGF-β1. Bar = 20 μm. All data are presented as means ± SDs. Jag1-fc, 1 μg/ml; TGF-β1, 5 ng/ml. *P < 0.05, **P < 0.05 versus the control; #P < 0.05 versus the Jag1-fc-treated group

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