Fig. 3
From: Notch pathway: a bistable inducer of biological noise?
Altered topology of the Wnt/β-catenin pathway in Notchon cells. a Left panels show network topology of simple feedback loops that regulate signalling output of the Wnt/β-catenin pathway in the Notchoff and the Notchon states. Line diagrams (right) show predicted impact of altered network topology the Notchon state on cytoplasmic availability of β-catenin, p53, and Myc. b Modeling demonstrates time course of equilibration of Myc and β-catenin subsequent to activation in the Notchoff and the Notchon states. Kinetic biochemical modeling was accomplished using VCell software