Fig. 2
From: Notch pathway: a bistable inducer of biological noise?
Altered topology of the PI3K/Akt pathway in Notchon cells. a The schematic diagram demonstrates inhibitory interactions of the PI3K/Akt cascade with major downstream suppressors of cell cycle progression. b Network topology of a simple negative feedback loop formed by PTEN/GSK3β/Akt in the Notchoff state (left graph) and subsequent to activation of Notch signalling (Notchon, right graph). The right graph shows potential impact of incorporating PTEN in I1-FFL loop in the Notchon state. c Modeling demonstrates time course of equilibration of Akt signalling subsequent to activation of the cascade by a single exposure to growth factors in the Notchoff (left graph) and the Notchon (right graph) states. Kinetic biochemical modeling was accomplished using VCell software. Schematic diagram (left) shows suppression of the Akt-mediated inhibition of p21 and p27 in the Notchon state