Fig. 1

Isoform-specific AKT signaling in tumor growth, metastasis, apoptosis and angiogenesis of breast cancer. Figure 1 provides an overview of isoform-specific AKT signaling in the regulation of tumor growth, metastasis, apoptosis and angiogenesis in breast cancer. Orange rectangles show AKT isoforms and splice variants, brown rectangles represent cellular effects in breast cancer. Ellipses indicate downstream effectors of AKT isoforms, hexagons indicate upstream regulators of AKT isoforms. Red colored shapes represent upstream and downstream proteins of AKT1, green colored shapes represent upstream and downstream proteins of AKT2 and blue colored shapes represent upstream and downstream proteins of AKT3. Yellow shapes represent effectors of AKT1 and AKT2, magenta shapes represent effectors of AKT1 and AKT3 and white shapes present effectors or regulators of AKT1, AKT2 and AKT3. The position of the arrow head symbolizes the direction of interaction. A plus associated with lines represents an activating or upregulating interaction, a minus represents a suppressing or downregulating interaction