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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Specific trophoblast transcripts transferred by extracellular vesicles affect gene expression in endometrial epithelial cells and may have a role in embryo-maternal crosstalk

Fig. 6

Embryo-derived extracellular vesicles (EVs) alter the expression of specific transcripts in endometrial cells. a, b Size profiles of embryo and embryo culture media derived nanoparticles strongly resemble a typical size profile of a population of comparable EVs. Gene expressions of c ZNF81, d Beta-2-microglobulin and e Beta actin in endometrial cells treated with human IVF day 3/5 normal/degenerating embryo-derived EVs, pure culture media derived EVs and untreated control. Isolated EVs were incubated with endometrial cells for 24 h and whole RNA of cells was quantified using qPCR. Data is presented as mean ± SEM. (*) p < 0.05 vs untreated control

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Cell Communication and Signaling

ISSN: 1478-811X