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Table 2 Transcriptomic data of glycolysis and lipogenesis pathways in 4NQO induced mouse tongue cancer group and in BME fed group

From: Inhibition of the key metabolic pathways, glycolysis and lipogenesis, of oral cancer by bitter melon extract

GenesCancer compared to normal (Fold)BME compared to cancer (Fold)
Glucose transporter-1 (Glut1/SLC2A1)8.13−2.9***
Hexokinase-1 (HK1)1.3−1.35*
Hexokinase-2 (HK2)1.41.07
Phosphofructo kinase (platelet) (PFKP)1.8***−1.4
Phosphogluco isomerase (GPI)−1.041.06
Triosphosphate isomerase (TPI)−1.1−1.1
Enolase- 1 (ENO-1)3.08***−1.8*
Pyruvate kinase muscle (PKM)1.2−1.3
Pyruvate dehydrogenase kinase 3 (PDK3)1.7**−1.1
Lactate dehydrogenase alpha (LDHA)1.9*−1.5
ATP Citrate Lyase (ACLY)1.2−1.3*
Acetyl-CoA Carboxylase 1 (ACC1)1.02−1.33
Fatty Acid Synthase (FASN)1.11−1.5*
  1. * P < 0.05; ** P < 0.01; ***P < 0.001