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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Inhibition of the key metabolic pathways, glycolysis and lipogenesis, of oral cancer by bitter melon extract

Fig. 2

BME treatment reduces pyruvate and lactate and glycolysis rate. a: Cal27 and JHU022 cells were treated with BME for 30 h and subjected to GC/MS analysis to determine levels of pyruvate and lactate. b: Cal27 and JHU022 cells were treated with BME for 24 h and 36 h. Extracellular acidification rate (ECAR) (glycolysis) was assessed using the Seahorse XF extracellular flux analyser. c: Relative glycolysis rate ECAR/OCR (oxygen consumption rate) was calculated at 36 h. Small bar indicates standard error (*, p < 0.05; **, p < 0.01; *** p < 0.001)

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