Fig. 5
Supplementation of linoleic acid to HF mice increased cardiolipin content and improved mitochondrial respiration and cardiac function. a. Cardiolipin contents (total, (18:2)4, (18:2)3(18:1)1, (18:2)3(22:6)1) in isolated heart mitochondria from HF mice fed a normal diet (n = 5) and HF mice fed a linoleic acid-rich diet (n = 5). b. Complex I-linked respiration, complex I + II-linked respiration, and complex II-linked respiration per heart mitochondrial protein in HF mice (n = 5) and HF mice fed a linoleic acid-rich diet (n = 5). c. LV function, LV end-diastolic diameter, and LV end-systolic diameter in HF mice fed a normal diet (n = 25) and HF mice fed a linoleic acid-rich diet (n = 8). Data are shown as the mean ± SE. LV, left ventricle. *p < 0.05 vs HF mice on a normal diet”