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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Notch1-ADAM8 positive feed-back loop regulates the degradation of chondrogenic extracellular matrix and osteoarthritis progression

Fig. 4

Inhibition of Notch signaling suppressed OA phenotype in vitro OA cell model. a: gene expression of Notch1, ADAM8 and MMP-9 were stimulated by IL-1β, however, were blocked by Notch inhibitor MW167. b: Western blotting results indicated that the protein level of Aggrecan, Collagen II were suppressed by IL-1β, however, were rescued by the treatment of Notch inhibitor MW167. c: immunofluorescence results indicated that the protein level of Aggrecan, Collagen II were suppressed by IL-1β, however, were rescued by the treatment of Notch inhibitor MW167. d: immunofluorescence results indicated that the protein level of ki67 was suppressed by IL-1β, however, was rescued by Notch inhibitor MW167. e; cell apoptosis of chondrocytes was induced by IL-1β, however, was blocked by MW167

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