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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Transcriptional activation of CBFβ by CDK11p110 is necessary to promote osteosarcoma cell proliferation

Fig. 2

CBFβ expression depends on CDK11 expression on transcriptional and translational levels. a Verification of the altered gene expression observed in the gene array for selected genes, including CBFβ and CDK11, using quantitative RT-PCR. Two different cell lines (KHOS and U-2OS) were analyzed, expression was normalized using the KHOS or U-2OS untreated control, and results were depicted as relative expression in these cells. b CDK11 siRNA downregulated the expression of CDK11 and CBFβ in a dose-dependent manner. KHOS or U-2OS cells were transfected with CDK11 siRNA with increasing concentrations. The protein expression of CBFβ decreased dependently with CDK11 expression. c Expressions of CDK11 and CBFβ in osteosarcoma cell lines and in normal osteoblast cell lines. d Expressions of CDK11 and CBFβ in osteosarcoma cell lines and metastatic cell lines. e Expressions of CDK11 and CBFβ in osteosarcoma tissues. *P < 0.05

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