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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Identification of Cancer–associated metabolic vulnerabilities by modeling multi-objective optimality in metabolism

Fig. 6

Over-expression of metabolic enzymes inhibits the Warburg effect. (a) KEGG pathways enriched in model-predicted Warburg effect-suppressing targets. (b) Monotonousness scores for model-predicted Warburg effect-suppressing enzymes. Enzymes selected for experimental validation are highlighted in red. (c-g) Relative values of ECAR/OCR ratio after 4 days upon (c) MDH2; (d) CTPS1; (e) CTPS2; (f) PYCR1; (g) PYCR2 over-expression in the tested cell lines. P-values were computed using Wilcoxon’s rank sum test. P-value< 0.05 was considered as significant

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