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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Identification of Cancer–associated metabolic vulnerabilities by modeling multi-objective optimality in metabolism

Fig. 5

Activation of lysine degradation pathway impairs cancer cell proliferation. (a) KEGG pathways enriched in model-predicted proliferation-suppressing targets. (b) Monotonousness scores for model-predicted proliferation-suppressing enzymes. Enzymes selected for experimental validation are highlighted in red. (c) Relative numbers of cells after 4 days upon AADAT over-expression in the tested cell lines. OE: over-expression. P-values were computed using Wilcoxon’s rank sum test. P-value< 0.05 was considered as significant. (d) Relative numbers of cells after 4 days upon AASS over-expression in the tested cell lines. P-values were computed using Wilcoxon’s rank sum test. P-value< 0.05 was considered as significant

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