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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Identification of Cancer–associated metabolic vulnerabilities by modeling multi-objective optimality in metabolism

Fig. 4

Experimental validation of proliferation-promoting targets. (a) KEGG pathways enriched in model-predicted proliferation-promoting targets. (b) Monotonousness scores for model-predicted proliferation-promoting enzymes. Enzymes selected for experimental validation are highlighted in red. (c-h) Relative number of cells after 4 days upon shRNA knockdown of (c) RPIA; (d) PHGDH; (e) PSAT1; (f) FTCD; (g) HAL; (h) UROC1 in the tested cell lines. P-values were computed using Wilcoxon’s rank sum test. P-value< 0.05 was considered as significant

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