Table 2 Downstream target genes of Nrf2 in pancreatic cancer

Antioxidant

Upregulated: NQO1, HO-1, SOD1, GCLC, HMOX1

[12]

Proliferation

Upregulated: NOTCH1, NPNT, BMPR1A, IGF1, ITGB2, PDGFC, VEGFC, JAG1

[53, 54]

Serine and glycine biosynthesis

Upregulated: ATF4, PHGDH, PSAT1, PSPH, SHMT1, SHMT2

[55, 56]

Stem cell self-renewal

Upregulated: NOTCH1, SIRT1, OCT4, NANOG, SOX2, BMI-1, BCL-2, TERT

[57, 58]

Cell cycle arrest

Upregulated: CDKN2B, CDKN1A, MDM2

[54, 59, 60]

Apoptosis

Upregulated: BCL-2, BCL-xL, HIPK2

Downregulated: NAF-1

[61]

Ferroptosis

Upregulated: MT-1G, FTL1, TH1, SLC11A3, AKR1C1, GPX4

[62, 63]

Senescence

Upregulated: MDM2, NOTCH1

[57, 64]

Autophagy

Upregulated: SQSTM1/p62, CALCOCO, ULK1, ATG5, GABARAPL1

[65]

Angiogenesis

Upregulated: NQO1, HMOX1, G6PD, PGK, TALDO, SLC7A11, PDGFC, FGF2

[66, 67]

Metastasis

Upregulated: NOTCH1, MMP2, MMP9, SPP1, GLO1, CDH2, FN1, TWIST2, SNAI1, SLUG

[14, 53, 68, 69]

Drug resistance

Upregulated: MRP1, MRP2, MRP3, MRP4, MRP5, ABCG2

[12, 18, 70]

Metabolic reprogramming

Upregulated: G6PD, PGD, TKT, TALDO1, ME1, IDH1, PPAT, MTHFD2, GLS

Downregulated: ACL, ACC1, FASN, SCD1, FADS1, FADS2, ELOVL2, ELOVL6

[71,72,73]

Immune surveillance

Upregulated: ATF3, IL-17D

Downregulated: IL-6

[13, 74]

Genome stability

Upregulated: OGG1,53BP1

[75, 76]

Proteotoxic stress

Upregulated: HMOX1, HSP70, SQSTM1/p62, ATF3, PSMA1, PSMA4, PSMA5, PSMB3, PSMB6, PSMC1, PSMC3, PSMD4, PSMD14, POMP

[77,78,79]