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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review

Fig. 4

Targeting Keap1-Nrf2 signaling pathway for pancreatic cancer prevention and therapy. Several strategies have been proposed to target the Nrf2 signaling pathway in human pancreatic cancer: (1) modulating Nrf2 expression at the transcriptional level, (2) modulating the Nrf2 activity by targeting its upstream activators and stabilizers, (3) affecting the nuclear translocation of Nrf2, (4) targeting the Keap1-Nrf2 binding for modulating Nrf2 protein stability, (5) targeting the β-TrCP-Nrf2 binding or the HRD1-Nrf2 binding and modulating Nrf2 ubiquitination and degradation, (6) modulating the binding of Nrf2 with its co-activators in the nucleus, and (7) modulating the binding of Nrf2 with its downstream target genes. Many small-molecule Nrf2 activators and inhibitors have been discovered and shown efficacy in pancreatic cancer cells in vitro and in vivo

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