Fig. 1
From: Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review
The dual roles of Keap1-Nrf2 signaling pathway in pancreatic cancer. In normal cells, Nrf2 is temporarily activated when exposed to electrophiles and ROS and activates the transcription of genes that increase the capabilities of detoxification, antioxidant, and immune surveillance, preventing chemical-induced carcinogenesis. In Nrf2-addicted cancer cells, Keap1 is deleted or expressed at a very low level. Nrf2 is overexpressed and constitutively activated and promotes cancer growth and metastasis by regulating its downstream target genes