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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Ventricular Zone Expressed PH Domain Containing 1 (VEPH1): an adaptor protein capable of modulating multiple signaling transduction pathways during normal and pathological development

Fig. 1

a Schematic showing the relationship between the human VEPH1 gene locus on the minus strand of chromosome 3, primary transcript, mature transcript, and encoded protein based upon data derived from NCBI AceView (http://www.ncbi.nlm.nih.gov/ieb/research/assembly). The protein sequence contains a conserved predicted N-terminal Armadillo-like fold and a C-terminal PH domain (www.ebi.ac.uk/interpro/protein/Q14D04), as well as two LLxxL nuclear receptor binding motifs. Three splice variants of the primary transcript have been reported with their predicted encoded products shown. Potential phosphorylation sites, identified by the Eukaryotic Linear Motif (ELM) resource prediction tool, are indicated with red text. TIR1 and TIR2 indicate sequences corresponding to the human protein that were shown to interact with TGFβ receptor 1 (ALK5). b Schematic showing the predicted proteins (Veph1A and Veph1B) encoded by full-length mouse Veph1 transcript and a reported alternatively spliced variant

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Cell Communication and Signaling

ISSN: 1478-811X