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Table 3 Univariate and multivariate COX regression analyses 4.1B for DFS or OS in GC patients

From: 4.1B suppresses cancer cell proliferation by binding to EGFR P13 region of intracellular juxtamembrane segment

Variables

DFS

OS

HR

95% CI

p value

HR

95% CI

p value

Univariate analysis

 4.1B expression (Positive vs. Negative)

2.654

1.626–4.332

< 0.001*

2.547

1.584–4.095

< 0.001*

 Age (< 65 years vs. ≥ 65 years)

1.092

0.676–1.766

0.719

0.879

0.551–1.400

0.586

 Gender (male vs. female)

0.910

0.558–1.482

0.704

0.953

0.593–1.530

0.841

 HP infection (Positive vs. Negative)

1.131

0.699–1.832

0.616

1.161

0.726–1.857

0.533

 Tumor size (<5 cm vs. ≥ 5 cm)

1.993

1.230–3.230

0.005*

2.260

1.403–3.640

0.001*

 Tumor location (Cardia+body vs. Antrum +Whole)

1.413

0.872–2.289

0.160

1.374

0.861–2.194

0.183

 WHO classification (Tubular +Signet-ring cell vs. Mucinous+ Others)

1.247

0.770–2.022

0.369

1.128

0.705–1.805

0.616

 Pathologic differentiation (G1 + G2 vs. G3)

1.229

0.867–1.742

0.247

1.066

0.771–1.473

0.699

 Vascular invasion (Positive vs. Negative)

1.229

0.752–2.010

0.411

1.142

0.709–1.840

0.584

 Neural invasion (Positive vs. Negative)

1.213

0.748–1.968

0.433

1.288

0.804–2.064

0.293

 Depth of invasion (T1 + T2 vs. T3 + T4)

1.429

0.814–2.508

0.214

0.938

0.563–1.563

0.807

 Lymph metastasis (N0 vs. N1 + N2 + N3)

2.266

1.211–4.238

0.010*

1.980

1.117–3.512

0.019*

 TNM stage (I + II vs. III)

2.317

1.428–3.760

0.001*

2.578

1.657–4.011

< 0.001*

Multivariate analysis

 4.1B expression (Positive vs. Negative)

1.773

1.036–3.035

0.037*

1.691

1.013–2.823

0.045*

 Tumor size (<5 cm vs. ≥ 5 cm)

1.694

1.023–2.803

0.040*

2.025

1.242–3.302

0.005*

 Lymph metastasis (N0 vs. N1 + N2 + N3)

1.724

0.903–3.289

0.099

1.458

0.807–2.632

0.211

 TNM stage (I + II vs. III)

1.923

1.161–3.184

0.011*

2.197

1.365–3.534

0.001*

  1. * p < 0.05