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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: 4.1B suppresses cancer cell proliferation by binding to EGFR P13 region of intracellular juxtamembrane segment

Fig. 3

Anti-tumor effects of 4.1B were evaluated in the nude mice. a- d Effects of 4.1B overexpression on tumor growth in the subcutaneous xenograft model. e- h Effects of 4.1B knock out on tumor growth in the subcutaneous xenograft model. a, e Images of stripped tumors from mice (n = 5 mice for each group). b, f Tumor growth curves showed that 4.1B overexpression reduced the growth of xenografts in nude mice, and 4.1B knock out promoted the growth of xenografts in nude mice. The values at each time point are shown as mean tumor size (mm3) ± SEM (standard error of the mean). c, g The weight of xenograft tumors at the time of sacrifice. Values are shown as mean tumor weight (g) ± SEM. d, h Ki-67 expression in xenograft tumors. * p < 0.05, ** p < 0.01, *** p < 0.001

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