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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1–mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma

Fig. 6

PH inhibits tumor growth via downregulating STAT3-related signaling pathway. a PH significantly inhibited tumor growth in HepG2 and SK-Hep1 tumor-bearing mice. b Tumor weight. c The in vivo SHP-1 phosphatase activity. d The protein levels of p-STAT3 and its downstream proteins were determined by Western blot assay. e STAT3 and related mRNA levels were analyzed by qPCR. f Kaplan–Meier plot showing animal survival after treatment with PH at indicated doses (n = 8). g Immunohistochemical staining (Left panel) of CD31, pSTAT3, cleaved caspase-3, Ki67 and TUNEL in tumor xenografts. Magnification: ×200. Data represents mean values from five random fields per tumor section. Scale bar, 50 μm. Mean values ± SD (bars) are shown. *p < 0.05, and **p < 0.01 compared to control

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Cell Communication and Signaling

ISSN: 1478-811X