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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1–mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma

Fig. 5

PH potentiates the effect of Sor in HepG2SR and Huh7SR cells in vitro. a Effect of PH (50 μM), Sor (10 μM) or both on p-STAT3 and its downstream proteins in SR-HCCs. b SHP-1 phosphatase activity in SR-HCCs exposed to PH, Sor or both for 48 h. c pSTAT3 activity was measured by ELISA. d Colony formation assay. e The protein levels of cleaved caspase-3 and -9 were determined by Western blot assay (f) DNA fragmentation assay for cells exposed to PH, Sor or both for 48 h. Experiments were conducted in triplicate and mean values ± SD (bars) are shown. *p < 0.05, and **p < 0.01 compared to control

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Cell Communication and Signaling

ISSN: 1478-811X