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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: cAMP- and cGMP-elevating agents inhibit GPIbα-mediated aggregation but not GPIbα-stimulated Syk activation in human platelets

Fig. 3

Syk-inhibitors strongly block EB-induced platelet aggregation. Human washed platelets (WP) were pre-incubated with 2 different Syk inhibitors, OXSI-2 (2 μM) and PRT-318 (1 μM) for 5 min prior to stimulation with EB. a Representative curves showing the effect of Syk inhibitors on platelet aggregation and b the corresponding quantification of data as means ± S.D. from 3 independent experiments with platelets from 3 healthy donors; ****p < 0.0001

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