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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism

Fig. 6

AO suppresses SW1990 tumor development in vivo. Tumor growth curve (a), mouse weight (b), and tumor weight (c) for SW1990 xenografts in CB-17/scid mice treated with 2.5 or 5 mg/kg/day AO or an equal volume of vehicle for 14 consecutive days. d Bioluminescence imaging of tumor at day 7. e Tumor tissues of xenograft mice after 14 days treatment. f NADPH/NADPH+ ratio in in tumor tissues from different groups. g Relative metabolite abundance in tumor tissues from different groups. The differences among groups were compared by analysis of variance (ANOVA). All data were presented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 compared with the vehicle control

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Cell Communication and Signaling

ISSN: 1478-811X