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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism

Fig. 5

AO induces apoptosis, cell cycle arrest and MMP loss in SW1990 cells in vitro. a SW1990 cells were treated with AO for 48 h, and the apoptotic cells were evaluated and quantified by Annexin V/PI staining. b Cell cycle analysis of SW1990 cells in control and AO treatment. c 14-day Colony formation assays for cells cultured in control and AO treatments. d DAPI and EdU double staining was used to determine the effect of different concentrations of AO on the proliferation of SW1990 cells. e, f Scratch wound healing of SW1990 cells was evaluated using cell scratch wound healing assay. Images from the same area were captured at time 0 h, 24 h and 48 h after wound infliction. The mean ± SD of three experiments is shown. *P < 0.05, **P < 0.01, ***P < 0.001 compared with the vehicle control

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Cell Communication and Signaling

ISSN: 1478-811X