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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism

Fig. 4

AO treatment induced Gln metabolism and modulates mitochondrial respiration. a Relative metabolite abundance in SW1990 cells treated with 10, 20, 40 μM AO. b NADP 1/NADPH ratio in in SW1990 cells treated with 10, 20, 40 μM AO. c, d Measurement of intracellular ROS using carboxyH2DCFDA in control and AO treatments. e, f OCR and ECAR analysis of SW1990 cells treated with 10 and 20 μM AO. *P < 0.05, **P < 0.01, ***P < 0.001 compared with the vehicle control

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Cell Communication and Signaling

ISSN: 1478-811X