Fig. 1From: Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolismGOT1 is selectively targeted by AO. a Schematic depiction of the sequential reactions that convert Asp into pyruvate, catalysed by GOT1, MDH1, and ME1. b The chemical structures of AO. c, d AO selectively inhibited homo and murine GOT1 activity. e, f MST assay of the KD value between AO and homo and murine GOT1. g, h The enzyme kinetics of AO on homo GOT1Back to article page