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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Inhibition of T cell immunoglobulin and mucin-1 (TIM-1) protects against cerebral ischemia-reperfusion injury

Fig. 3

TIM-1 disruption effectively reduced neutrophil and macrophage function in the brain tissue. a and b Immunohistochemical staining was used to analyze the number of CD3 and CD68 macrophages, as well as Ly6G neutrophils. c qRT-PCR was used to examine the expression of interleukin (IL-6), chemokine (C-X-C motif) ligand 1 (CXCL1), CXCL-2, IL-1β, and tumor necrosis factor alpha (TNF-α). **p < 0.01; ***p < 0.001. d qRT-PCR was used to detect the level of TIM-1 expression following treatment with or without an anti-TIM-1 Ab in the MCAC model or Black group. *p < 0.05; **p < 0.01. e and f Western blot analysis of the level of TIM-1 expression following treatment with or without an anti-TIM-1 Ab in the MCAC model or Black group. **p < 0.01. g and h An ELISA was used to examine the level of MPO and LDH expression. i Flow cytometry detection of TIM-1 expression

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