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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Increased HERV-E clone 4–1 expression contributes to DNA hypomethylation and IL-17 release from CD4+ T cells via miR-302d/MBD2 in systemic lupus erythematosus

Fig. 1

HERV-E clone 4–1 mRNA expression was upregulated in CD4+ T cells from SLE patients. a and b) Relative expression of HERV-E clone 4–1 mRNA in CD4+ cells from SLE patients (N = 27) and healthy controls (HCs) (N = 21) or active SLE patients (N = 24) and inactive SLE patients (N = 3) compared using the unpaired Student’s t test. c Correlation between expression of HERV-E clone 4–1 mRNA and SLEDAI score analyzed with Spearman’s analysis. d and e SLEDAI score and HERV-E clone 4–1 mRNA expression in patients who got oral prednisolone and hydroxychloroquine treatment (N = 9); data were compared using the paired Student’s t test. f Relative expression of HERV-E clone 4–1 mRNA in CD4+ cells from inactive SLE patients (N = 11) and HCs (N = 21) compared using the unpaired Student’s t test. g ROC curve of relative HERV-E clone 4–1 mRNA expression for differentiating SLE patients from HCs. Data were represented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001

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Cell Communication and Signaling

ISSN: 1478-811X