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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells

Fig. 8

9F7-F11 induces downregulation of the pro-survival proteins c-IAP2 and XIAP. Cells were incubated with 9F7-F11, before western blot analysis of cIAP2 and XIAP (survival factors) and of UP9X (deubiquitinase) expression in protein lysates prepared at different time points. Quantification of signal intensity (SI) with ImageJ software is indicated below the images (relative to untreated control measured as 1.0 ± .0). Significant increase or decrease of the densitometry, compared to control, is indicated in bold. β-tubulin was evaluated as loading control

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Cell Communication and Signaling

ISSN: 1478-811X