Skip to main content
Fig. 7 | Cell Communication and Signaling

Fig. 7

From: ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells

Fig. 7

9F7-F11 activates the intrinsic mitochondrial apoptosis pathway by inducing caspase-8-mediated BID cleavage, BAX activation and BIM expression. BxPC3 (a), MDA-MB-468 and DU145 (b) cells were incubated with 9F7-F11 for various times. BID cleavage (tBID), BAX activation and BIM expression were analyzed by western blotting. Quantification of signal intensity (SI) with ImageJ software is indicated below the images. No protein expression was measured as 0.0 ± .0. Significant decrease or increase of the densitometry, compared to untreated control, is indicated in bold. β-tubulin was evaluated as loading control

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X