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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: Estrogen inhibits autophagy and promotes growth of endometrial cancer by promoting glutamine metabolism

Fig. 8

Schematic diagram of estrogen-Gln metabolism in estrogen-sensitive UECC. For estrogen-sensitive UEC, estrogen remarkably increases GLS and activates glutamine metabolism through up-regulating c-MYC. These processes remarkably lead to enhanced cell viability and decreased autophagy of estrogen-sensitive UECC. The GLS inhibitor CB-839 restricts the effects of estrogen on UECC’s growth and autophagy by inhibiting Gln metabolism

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