Fig. 1
From: Wnt signaling: a promising target for osteoarthritis therapy
The signaling transduction cascades and cell-specific role of β-catenin-dependent canonical Wnt signaling pathway in regulating chondrocyte, synovial cells and osteoblast metabolism, whereby mediating the process of cartilage degradation, synovium inflammation, as well abnormally activited subchondral bone remodelling in OA development. Events induced by Wnt or β-catenin targeted angonist of antagonist/inhibitor, including DKK1, WISP-1, FRZB, SOST and Fibutlin-4, are marked with event-specific colored line or arrows