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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Reversal effect of FW-04-806, a macrolide dilactone compound, on multidrug resistance mediated by ABCB1 and ABCG2 in vitro and in vivo

Fig. 5

Effect of FW-04-806 on the efflux of DOX and the ATPase activity of ABCB1. The DOX retention was measured by flow cytometry in KBv200 (a) and S1-MI-80 cells (b). The cells were preincubated with 10 μmol/L of DOX at 37 °C for 3 h and then incubated with or without FW-04-806 for indicated time points in DOX-free media, the samples at different time point were measured by flow cytometry. Effect of FW-04-806 on ATPase activity of ABCB1 (c). Data represent mean ± SD from three independent experiments. **P < 0.01

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Cell Communication and Signaling

ISSN: 1478-811X