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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Reversal effect of FW-04-806, a macrolide dilactone compound, on multidrug resistance mediated by ABCB1 and ABCG2 in vitro and in vivo

Fig. 4

Effect of FW-04-806 on the intracellular accumulation of Rho123 in MDR cells and their parental sensitive cells. The intracellular accumulation of Rho123 in KBv200 and KB (a), K562/adr and K562 (b), MCF-7/adr and MCF-7 (c), HEK293/ABCB1 and HEK293/pcDNA3.1 cells (d) was measured by flow cytometric analysis. A representative result from three independent experiments was shown. The accumulation of Rho123 was quantified as fold change in fluorescence intensity of Rho123 relative to the control MDR cells treated with vehicle and Rho123, it was calculated with dividing the fluorescence intensity of each sample by that of MDR cells treated with vehicle and Rho123. Data are expressed as mean ± SD from three independent experiments. * P < 0.05; ** P < 0.01

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Cell Communication and Signaling

ISSN: 1478-811X