Fig. 3From: Reversal effect of FW-04-806, a macrolide dilactone compound, on multidrug resistance mediated by ABCB1 and ABCG2 in vitro and in vivoEffect of FW-04-806 on the intracellular accumulation of DOX in MDR cells and their parental sensitive cells. The intracellular accumulation of DOX in KBv200 and KB (a), K562/adr and K562 (b), MCF-7/adr and MCF-7 (c), S1-MI-80 and S1 cells (d) was measured by flow cytometric analysis. A representative diagram from three independent experiments was shown. The accumulation of DOX was quantified as fold change in fluorescence intensity of DOX relative to the control MDR cells treated with vehicle and DOX, it was calculated with dividing the fluorescence intensity of each sample by that of MDR cells treated with vehicle and DOX. Data are expressed as mean ± SD from three independent experiments. * P < 0.05; ** P < 0.01Back to article page