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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Caffeic acid phenethyl ester suppresses androgen receptor signaling and stability via inhibition of phosphorylation on Ser81 and Ser213

Fig. 5

CAPE treatment suppressed phosphorylation of AR on Ser81 and expression level of CDK1. Protein level of phospho-AR Ser81, CDK1, phospho-CDK1 T161, Cyclin B1, CDK5, and CDK9 in LNCaP 104-S (a) and 104-R1 (b) cells treated with DHT (0, 1, 10 nM) and CAPE (0, 10, 20, 40 μM) for 48 h was determined by Western blotting. The mRNA level of CDK1 in LNCaP 104-S (c) and LNCaP 104-R1 cells (d) treated with indicated concentration of DHT and CAPE for 48 h was analyzed by qRT-PCR. GAPDH was used as loading control. Asterisks *, **, and *** represented statistical significance p < 0.05, p < 0.01, and p < 0.001, respectively, between the treatment group and the control group

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Cell Communication and Signaling

ISSN: 1478-811X