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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Protein phosphatase 2A modulates podocyte maturation and glomerular functional integrity in mice

Fig. 5

Loss of podocyte PP2A results in a modest reduction of the expression of some epithelial cell markers. a Expression of WT1 in glomeruli from Pod-PP2A-KO mice and control at 5 weeks of age. Scale bar: 50 μm. b Quantification of WT1 staining in podocytes per glomerulus from a. n = 6 experiments. No significant loss of WT1 expression was seen between the podocytes from Pod-PP2A-KO mice and control. c The results of Tunel assay in glomerulus and tubules demonstrate that there is no apoptosis in the PP2A knockout mice. d Quantification of immunofluorescence density for synaptopodin, podocin and nephrin per glomerulus, n = 6 experiments. e The expression of synaptopodin, podocin and nephrin in glomeruli by immunofluorescence and confocal microscopic from Pod-PP2A-KO mice and control. Scale bar: 50 μm

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